小動(dòng)物無(wú)創(chuàng)超聲多普勒血流系統(tǒng)
產(chǎn)品詳情介紹
總覽
Indus 超聲多普勒血流系統(tǒng) (DFVS) 是一項(xiàng)技術(shù)成熟且能夠大幅度消減實(shí)驗(yàn)成本并取代傳統(tǒng)成像技術(shù)的系統(tǒng)。小型手持式探針能夠輕松、穩(wěn)定地測(cè)量小動(dòng)物心臟血液流動(dòng)情況，成功提高心臟動(dòng)脈研究效率。
多普勒血流系統(tǒng)采用了高頻多普勒脈沖探測(cè)裝置，能通過(guò)專業(yè)的集成數(shù)據(jù)分析軟件分析小動(dòng)物心血管功能狀況。其高采集頻率所帶來(lái)的高成像分辨率使得它能夠成為研究小鼠及其他小動(dòng)物心臟血流速度的理想工具。
該系統(tǒng)由三部分裝置組成： 脈沖多普勒收發(fā)器（PDT: 10 & 20 MHz 可切換雙通道系統(tǒng)），多普勒信號(hào)數(shù)字采集器 (DSD)，和多普勒工作站軟件 (DW)。
產(chǎn)品特征
連續(xù)的測(cè)量與反饋以保障測(cè)量的準(zhǔn)確性
可以在不同條件下評(píng)估心臟收縮與舒張功能
可以通過(guò)比較左右頸動(dòng)脈速度判斷主動(dòng)脈狹窄(TAC)情況
壓力灰階能夠估計(jì)主動(dòng)脈狹窄TAC的血流速度
測(cè)量充血速度評(píng)估冠狀動(dòng)脈血流的儲(chǔ)備，而心臟功能會(huì)受到疾病、年齡、壓力/體積的影響
冠狀動(dòng)脈血流分布可以通過(guò)收縮壓/舒張壓流動(dòng)比率的變化體現(xiàn)
參考文獻(xiàn)
Anti-aging gene klotho de?ciency promoted high fat diet-induced arterial stiffening via inactivation of AMP-activated protein kinase. Lin Y, Chen J, Sun Z. Hypertension, 67:564-573, (2016). PMID: 26781278
And the beat goes on: attenuated cardiovascular aging in the longest-lived rodent,the naked mole-rat.
Grimes KM, Reddy AK, Lindsey ML, Buffenstein R. Am J Physiol Heart Circ Physiol, 307:H284-H291, (2014).PMID: 24906918
Inhibition of glycosphingolipid synthesis ameliorates atherosclerosis and arterial stiffness in apolipoprotein E-/- mice and rabbits fed a high-fat and -cholesterol diet.Chatterjee S, Bedja D, Mishra S, Amuzie C, Avolio A, Kass DA, Berkowitz D, Renehan M. Circulation, 129:2403-2413,(2014). PMID: 24710030 Rnd3 haploinsu?cient mice are predisposed to hemodynamic stress and develop apoptotic cardiomyopathy with heart failure.
Yue X, Yang X, Lin X, Yang T, Yi X, Dai Y, Guo J, Li T, Shi J, Wei L, Fan GC, Chen C, Chang J. Cell Death Disease, 5:e1284,(2014). PMID: 24901055 Genetic de?ciency of anti-aging gene klotho exacerbates early nephropathy in STZ-induced diabetes in male mice.
Lin Y, Kuro-o M, Sun Z. Endocrinology, 154:3855-3863, (2013). PMID: 23928372 Hartley CJ, Reddy AK, Madala S, Entman ML, Michael LH, Taffet GE. Am J Physiol Heart Circ Physiol, 301: H269-H278, (2011). PMID: 21572013 Pulsed Doppler signal processing for use in mice: applications.
Reddy AK, Taffet GE, Li, Y-H, Lim S-W, Pham TT, Pocius JS, Entman ML, Michael LH, Hartley CJ. IEEE Trans Biomed Eng, 52:1771-1783, (2005). PMID: 16235663
